MEMBRANE DEPOLARIZATION COUPLESCa2+ SPARKS TO KCa CHANNELS IN NEWBORN ARTERIAL SMOOTH MUSCLE CELLS
نویسندگان
چکیده
منابع مشابه
KCa channel insensitivity to Ca sparks underlies fractional uncoupling in newborn cerebral artery smooth muscle cells
Li, Anlong, Adebowale Adebiyi, Charles W. Leffler, and Jonathan H. Jaggar. KCa channel insensitivity to Ca sparks underlies fractional uncoupling in newborn cerebral artery smooth muscle cells. Am J Physiol Heart Circ Physiol 291: H1118–H1125, 2006. First published April 7, 2006; doi:10.1152/ajpheart.01308.2005.—In smooth muscle cells, localized intracellular Ca transients, termed “Ca sparks,” ...
متن کاملKCa channel insensitivity to Ca2+ sparks underlies fractional uncoupling in newborn cerebral artery smooth muscle cells.
In smooth muscle cells, localized intracellular Ca2+ transients, termed "Ca2+ sparks," activate several large-conductance Ca2+-activated K+ (KCa) channels, resulting in a transient KCa current. In some smooth muscle cell types, a significant proportion of Ca2+ sparks do not activate KCa channels. The goal of this study was to explore mechanisms that underlie fractional Ca2+ spark-KCa channel co...
متن کاملFunctional Coupling of Ryanodine Receptors to KCa Channels in Smooth Muscle Cells from Rat Cerebral Arteries
The relationship between Ca2+ release ("Ca2+ sparks") through ryanodine-sensitive Ca2+ release channels in the sarcoplasmic reticulum and KCa channels was examined in smooth muscle cells from rat cerebral arteries. Whole cell potassium currents at physiological membrane potentials (-40 mV) and intracellular Ca2+ were measured simultaneously, using the perforated patch clamp technique and a lase...
متن کاملCarbon monoxide activates KCa channels in newborn arteriole smooth muscle cells by increasing apparent Ca sensitivity of -subunits
Xi, Qi, Dilyara Tcheranova, Helena Parfenova, Burton Horowitz, Charles W. Leffler, and Jonathan H. Jaggar. Carbon monoxide activates KCa channels in newborn arteriole smooth muscle cells by increasing apparent Ca sensitivity of -subunits. Am J Physiol Heart Circ Physiol 286: H610–H618, 2004. First published October 16, 2003; 10.1152/ajpheart.00782.2003.—Carbon monoxide (CO) is a gaseous vasodil...
متن کاملCarbon monoxide activates KCa channels in newborn arteriole smooth muscle cells by increasing apparent Ca2+ sensitivity of alpha-subunits.
Carbon monoxide (CO) is a gaseous vasodilator produced by many cell types, including endothelial and smooth muscle cells. The goal of the present study was to investigate signaling mechanisms responsible for CO activation of large-conductance Ca(2+)-activated K(+) (K(Ca)) channels in newborn porcine cerebral arteriole smooth muscle cells. In intact cells at 0 mV, CO (3 microM) or CO released fr...
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ژورنال
عنوان ژورنال: The FASEB Journal
سال: 2006
ISSN: 0892-6638,1530-6860
DOI: 10.1096/fasebj.20.4.a304-d